8 Factors that can cause protein denaturation

• Heat, which can disrupt hydrogen bonds and non-polar hydrophobic interactions.
• Freezing, which can cause ice crystals to form and damage the protein structure.
• pH change, which can alter the charge and polarity of amino acids and affect their interactions.
• Ionic strength change, which can affect the electrostatic forces between amino acids and their surroundings.
• Surface changes, which can expose the protein to different environments and solvents.
• exposure to UV light and radiation breaks bond in the proteins
• chemicals such as alcohol and heavy metals precipitate proteins from solution
• mechanical agitation can distort protein structures leading to denaturation

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Dr. Bbosa Science