Draw a fully labelled diagram of a neurotransmitter junction and explain how the impulse cross the neuromuscular junction.

Structure of neuromuscular junction

How impulse cross neuromuscular junction

• Arrival of impulse causes the calcium voltage gates to open leading to influx of calcium ions from the synaptic cleft.
• The Ca²⁺ ion causes the synaptic vesicles to move towards the pre-synaptic membrane.
• The vesicles fuse with the pre- synaptic membrane and release a transmitter substance into the synaptic cleft by exocytosis.
• The transmitter substance diffuses across the synaptic cleft and attaches to specific receptor sites on the post synaptic membrane.
• This causes an influx of Na⁺ ion into post- synaptic membrane, resulting in local depolarization of the membrane. If the Na⁺ ion surge is large enough, an action potential (impulse) is generated in the post –synaptic neuron.

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