Hormonal control of spermatogenesis in humans

Hormonal control of spermatogenesis in humans

• The hypothalamus secretes gonadotrophin releasing hormone (GnRH) which in turn stimulates the anterior pituitary gland to secrete two hormones; follicle stimulating hormone (FSH) and luteinizing hormone (LH)
• FSH stimulates spermatogenesis by stimulating the Sertoli cells to complete the development of spermatozoa from spermatids.
• LH stimulates the synthesis of the hormone, testosterone by the leydig cells of the testis. LH is also called the interstitial cell stimulating hormone (ICSH) in the male.
• Testosterone stimulates growth and development of the germinal epithelial cells (spermatogonia) to form sperms. It also works with FSH to stimulate the sertoli cells. By negative feedback mechanism, testosterone regulates the secretion of other hormones responsible for spermatogenesis.

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