How does resistance of malarial parasite to antimalarial drugs occur?

How does resistance of malarial parasite to antimalarial drugs occur?

How does resistance of malarial parasite to antimalarial drugs occur?

  • Failure of the parasite to absorb the drug
  • Formation of inaccessible forms during its development life cycle in man (tissue hypnozoites)
  • Parasite may use alternative biosynthetic pathway not affected by the drug.
  • The parasite tissue may become tolerant to drug molecules
  • parasite may produce enzymes that destroy the drug

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