How does resistance of malarial parasite to antimalarial drugs occur?
How does resistance of malarial parasite to antimalarial drugs occur?
- Failure of the parasite to absorb the drug
- Formation of inaccessible forms during its development life cycle in man (tissue hypnozoites)
- Parasite may use alternative biosynthetic pathway not affected by the drug.
- The parasite tissue may become tolerant to drug molecules
- parasite may produce enzymes that destroy the drug
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