How is cartilage replaced by bone?

How is cartilage replaced by bone?

• the process by which cartilages is replace by bone is called endochondral ossification.
• A primary center of ossification appears in the middle of the shaft. The chondroblasts arranged in rows, divide rapidly, and become hypertrophied.
• Calcium and phosphates salts are laid down in the matrix.
• These changes begin in the center and move outwards. At this stage, we have calcified cartilage and the perichondrium becomes periosteum
• Osteoblast lay down fibers on the surface of cartilage.
• Cartilage then become calcified to form a compact bone.
• Osteoclasts erode through bones into cartilage to make canals for blood vessels

Osteoblast deposit bone salts in the spaces created to be able to strengthen the bone

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